This International Research Laboratory (IRL) from the French state research organization CNRS is the first in the field of biological science in South America (CNRS Biology) and the second worldwide. It is located in the University of Sao Paulo (USP) campus of Ribeirão Preto in São Paulo state.
It is the culmination of 10+ years of collaboration between the CNRS INEM laboratory in Orleans, France and colleagues in Brazil. The collaboration with the USP Brazil was initiated in the field of pulmonary inflammation from allergic, non-allergic or of infectious origin. We studied several aspects of these responses within the framework of collaborative projects: PICS, CNRS-FAPESP and the “laboratoire International Associé” (LIA) “Pulmonary inflammation” (2012-2018), extended with the International Research Project (IRP) “Immune response to danger signals” (2019 – 2023) to new areas of interest, including the response to endogenous or exogenous DNA and neuroinflammation. Our complementarity has enabled very fruitful interactions, including >100 research visits or stays of up to 1 year for scientific managers but also for post-doctoral or doctoral students from both countries.
A CNRS international Research Center (IRC) has been inaugurated in on March 27th 2024 in São Paulo at the CNRS house. During this ceremony, the agreement establishing the creation of our International Research Laboratory IMHEA CNRS between the USP – Universidade de São Paulo and the CNRS was signed by the rector of the USP Prof. Dr. Carlos Gilberto Carlotti Jr and the president of the CNRS Antoine Petit.
List of former collaborative publications:
Cutrin JC, Alves-Filho JC, Ryffel B.Front Immunol. 2023 Nov 22;14:1325020. doi: 10.3389/fimmu.2023.1325020.
eCollection 2023.PMID: 38077361
S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity.
Silva de Melo BM, Veras FP, Zwicky P, Lima D, Ingelfinger F, Martins TV, da Silva Prado D, Schärli S, Publio G, Hiroki CH, Melo PH, Saraiva A, Norbiato T,
Lima L, Ryffel B, Vogl T, Roth J, Waisman A, Nakaya HI, da Silva Souza C, Cunha FQ, Cunha TM, Becher B, Alves-Filho JC.J Invest Dermatol. 2023 Sep;143(9):1678-1688.e8. doi: 10.1016/j.jid.2023.02.026. Epub 2023 Mar 13.PMID: 36921684
Nascimento DC, Viacava PR, Ferreira RG, Damaceno MA, Piñeros AR, Melo PH, Donate PB, Toller-Kawahisa JE, Zoppi D, Veras FP, Peres RS, Menezes-Silva L,
Caetité D, Oliveira AER, Castro ÍMS, Kauffenstein G, Nakaya HI, Borges MC, Zamboni DS, Fonseca DM, Paschoal JAR, Cunha TM, Quesniaux V, Linden J, Cunha
FQ, Ryffel B, Alves-Filho JC.Immunity. 2021 Sep 14;54(9):2024-2041.e8. doi:10.1016/j.immuni.2021.08.005. Epub 2021 Sep 1.PMID: 34473957
MMP-9 Mediates Cross-Talk between Neutrophils and Endothelial Cells in Psoriasis.
Alves-Filho JC, Marcel Silva Melo B, Ryffel B.J Invest Dermatol. 2021 Apr;141(4):716-718. doi:10.1016/j.jid.2020.09.006.PMID: 33752809
Nehmar R, Fauconnier L, Alves-Filho J, Togbe D, DeCauwer A, Bahram S, Le Bert M, Ryffel B, Georgel P.J Cell Mol Med. 2021 May;25(10):4721-4731. doi:
10.1111/jcmm.16433. Epub 2021 Mar 18.PMID: 33734594
Molecular basis of carrageenan-induced cytokines production in macrophages.
Lopes AH, Silva RL, Fonseca MD, Gomes FI, Maganin AG, Ribeiro LS, Marques LMM, Cunha FQ, Alves-Filho JC, Zamboni DS, Lopes NP, Franklin BS, Gombault A, Ramalho FS, Quesniaux VFJ, Couillin I, Ryffel B, Cunha TM.
Cell Commun Signal. 2020 Sep 7;18(1):141. doi:10.1186/s12964-020-00621-x.PMID: 32894139
Luiz JPM, Toller-Kawahisa JE, Viacava PR, Nascimento DC, Pereira PT, Saraiva AL, Prado DS, LeBert M, Giurisato E, Tournier C, Cunha TM, Cunha FQ, Quesniaux V, Ryffel B, Alves-Filho JC.J Leukoc Biol. 2020 Oct;108(4):1215-1223. doi: 10.1002/JLB.1MA0520-016R. Epub 2020 Aug 3.PMID: 32745297
ILC2s and Basophils Team Up to Orchestrate IL-33-Induced Atopic Dermatitis.
Ryffel B, Alves-Filho JC.J Invest Dermatol. 2019 Oct;139(10):2077-2079. doi: 10.1016/j.jid.2019.06.118.PMID: 31543211
Saraiva AL, Veras FP, Peres RS, Talbot J, de Lima KA, Luiz JP, Carballido JM, Cunha TM, Cunha FQ, Ryffel B, Alves-Filho JC.FASEB J. 2018 Jun 12:fj201800285. doi:
10.1096/fj.201800285. Online ahead of print.PMID: 29894669
Talbot J, Peres RS, Pinto LG, Oliveira RDR, Lima KA, Donate PB, Silva JR, Ryffel B, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, de Queiroz Cunha F.Arthritis Res Ther. 2018 Jun 8;20(1):119. doi: 10.1186/s13075-018-1609-9.PMID: 29884199
Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain.
Zarpelon AC, Rodrigues FC, Lopes AH, Souza GR, Carvalho TT, Pinto LG, Xu D, Ferreira SH, Alves-Filho JC, McInnes IB, Ryffel B, Quesniaux VF, Reverchon F, Mortaud S, Menuet A, Liew FY, Cunha FQ, Cunha TM, Verri WA Jr.FASEB J. 2016 Jan;30(1):54-65. doi: 10.1096/fj.14-267146. Epub 2015 Aug 26.PMID: 26310268
Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model.
Carlos D, Spiller F, Souto FO, Trevelin SC, Borges VF, de Freitas A, Alves-Filho JC, Silva JS, Ryffel B, Cunha FQ.J Immunol. 2013 Aug1;191(3):1373-82. doi: 10.4049/jimmunol.1202907. Epub 2013 Jul 1.PMID: 23817413
Garcia CC, Weston-Davies W, Russo RC, Tavares LP, Rachid MA, Alves-Filho JC, Machado AV, Ryffel B, Nunn MA, Teixeira MM.PLoS One. 2013 May 16;8(5):e64443. doi: 10.1371/journal.pone.0064443. Print 2013.PMID: 23696894
Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.
Secher T, Vasseur V, Poisson DM, Mitchell JA, Cunha FQ, Alves-Filho JC, Ryffel B.J Immunol. 2009 Jun 15;182(12):7855-64. doi: 10.4049/jimmunol.0804008.PMID: 19494310
IL-17 receptor signaling is required to control polymicrobial sepsis.
Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sônego F, Cunha FQ, Ryffel B.J Immunol. 2009 Jun 15;182(12):7846-54. doi: 10.4049/jimmunol.0803039.PMID: 19494309
